Coronary inflammation and cardiovascular risk in breast cancer after radiotherapy | Kotanidis et al
Introduction
Radiotherapy (RT) is known to reduce the rate of disease recurrence following breast-conserving surgery in patients with breast cancer, but also entails irradiation of the heart, which can lead to cardiotoxicity and vascular injury, specifically through sustained inflammation.1 During the last decades, RT advancements have been made in limiting the heart dose and the link between RT and long-term cardiovascular risk is less clear, with some older studies highlighting a dose-dependent increase in the subsequent rate of ischaemic heart disease,2 while more recent studies showed no evidence for increased cardiac mortality among women treated with RT.3 We sought to explore the evolution of coronary inflammation and residual inflammatory risk 2 years after RT in women with breast cancer.
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Christos P Kotanidis, Thomas Halborg, Pete Tomlins, Kenneth Chan, Sam Fry, Gaëlle Jimenez, Matthieu Lapeyre, Nikant Sabharwal, Keith M Channon, Stefan Neubauer, Sophie Jacob, Charalambos Antoniades, Coronary inflammation and cardiovascular risk in breast cancer after radiotherapy, European Heart Journal, 2025;, ehaf260, https://doi.org/10.1093/eurheartj/ehaf260
